<html>
  <head>

    <meta http-equiv="content-type" content="text/html; charset=utf-8">
  </head>
  <body text="#000000" bgcolor="#FFFFFF">
    <!--[if gte mso 9]><xml>
 <o:DocumentProperties>
  <o:Author>Folaposi Wendy Oyedele</o:Author>
  <o:Version>14.00</o:Version>
 </o:DocumentProperties>
 <o:OfficeDocumentSettings>
  <o:AllowPNG/>
 </o:OfficeDocumentSettings>
</xml><![endif]-->
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal"><b style="mso-bidi-font-weight:normal"><span
style="font-family:"Arial","sans-serif";mso-fareast-font-family:"Times
          New Roman";
          mso-fareast-language:EN-GB">Dear colleagues</span></b></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal"><span
style="font-family:"Arial","sans-serif";mso-fareast-font-family:"Times
        New Roman";mso-fareast-language:EN-GB">We are seeking two
        motivated and
        creative Post Doctoral Researchers for structural and molecular
        biology studies
        to </span><span
        style="font-family:"Arial","sans-serif"">understand
        how DNA
        replication is initiated and regulated in the cell cycle</span><span
style="font-family:"Arial","sans-serif";mso-fareast-font-family:"Times
        New Roman";
        mso-fareast-language:EN-GB">. The research will be performed by
        the team led by
        Prof Elena Orlova (ISMB, Birkbeck, London) and Dr. Cyril Sanders
        (</span><span
        style="font-family:"Arial","sans-serif"">University
        of Sheffield). In the lab
        by Dr Sanders the discrete protein-DNA complexes will be
        assembled, purified
        and characterised for their distortions, melting and then
        unwinding of the DNA
        double helix. Structures of replication complexes will be
        determined using cryo
        electron microscopy (cryo-EM) in the lab of Prof Orlova at
        Birkbeck College
        (ISMB) in London. The opportunities offered by the “resolution
        revolution” in
        cryo-EM make this is an exciting time to be involved in
        mechanistic
        biochemistry. The full-time posts are funded by the
        Biotechnology and
        Biological Sciences Research Council (BBSRC) and are available
        for a period of
        3 years.</span><span
style="font-family:"Arial","sans-serif";mso-fareast-font-family:"Times
        New Roman";mso-fareast-language:EN-GB"></span></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal"><b style="mso-bidi-font-weight:normal"><u><span
style="font-family:"Arial","sans-serif";mso-fareast-font-family:"Times
            New Roman";
            mso-fareast-language:EN-GB">Post 1</span></u></b></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal;mso-hyphenate:none;tab-stops:center 225.65pt"><b
        style="mso-bidi-font-weight:normal"><span
          style="font-family:"Arial","sans-serif";
          mso-fareast-font-family:"Times New
          Roman";mso-fareast-language:EN-GB">Post
          Doctoral Researcher - Structural Biology<span
            style="mso-bidi-font-weight:bold">
          </span>(Ref: </span></b><b
        style="mso-bidi-font-weight:normal"><span
          style="font-family:"Arial","sans-serif";color:black">12339</span></b><b
        style="mso-bidi-font-weight:normal"><span
          style="font-family:"Arial","sans-serif";
          mso-fareast-font-family:"Times New
          Roman";mso-fareast-language:EN-GB">)</span></b></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal;mso-outline-level:5"><b><span
          style="font-family:"Arial","sans-serif";
          mso-fareast-font-family:"Times New
          Roman";mso-fareast-language:EN-GB">Postdoctoral
          positions in cryo-EM structural biology at </span></b><b><span
style="font-family:"Arial","sans-serif";mso-fareast-font-family:"Times
          New Roman";
          mso-ansi-language:EN-US;mso-fareast-language:EN-GB"
          lang="EN-US">Institute of Structural and
          Molecular Biology (ISMB), Birkbeck College, London</span></b><b
        style="mso-bidi-font-weight:normal"><span
          style="font-family:"Arial","sans-serif";
          mso-fareast-font-family:"Times New
          Roman";mso-fareast-language:EN-GB" lang="EN-US"> </span></b><b
        style="mso-bidi-font-weight:normal"><span
          style="font-family:"Arial","sans-serif";
          mso-fareast-font-family:"Times New
          Roman";mso-fareast-language:EN-GB"></span></b></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal;mso-outline-level:5"><b
        style="mso-bidi-font-weight:normal"><span
style="font-family:"Arial","sans-serif";mso-fareast-font-family:"Times
          New Roman";
          mso-fareast-language:EN-GB">Department of Biological Sciences</span></b></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal;mso-hyphenate:none;tab-stops:center 225.65pt"><b
        style="mso-bidi-font-weight:normal"><span
          style="font-family:"Arial","sans-serif";
          mso-fareast-font-family:"Times New
          Roman";mso-fareast-language:EN-GB">Full
          time, fixed term appointment for up to 3 years </span></b><span
style="font-family:"Arial","sans-serif";mso-fareast-font-family:"Times
        New Roman";
        mso-fareast-language:EN-GB"> </span></p>
    <p class="MsoNormal" style="margin-bottom:.1pt;line-height:normal"><span
style="font-family:"Arial","sans-serif";mso-fareast-font-family:"Times
        New Roman";
        mso-fareast-language:EN-GB">A postdoctoral position is available
        for cryo-EM
        analysis of </span><span
        style="font-family:"Arial","sans-serif";color:black">complexes
        formed by two viral proteins, E1 and E2 and a specific dsDNA
        sequence to
        understand replication initiation. Cryo-EM and single-particle
        analysis (SPA)
        allow visualisation of particles in solution under near-native
        conditions. The
        specific objectives are to determine the structure of the
        E1E2-ori
        pre-initiation complex and reveal the ATP-dependent
        conformational changes in
        the protein and DNA, to derive a high-resolution cryo-EM
        structure of the E1
        helicase bound to a replication fork junction (RFJ)-like DNA
        substrate. It is
        important for both experimental design and interpretation of
        results to have
        active scientific interactions with the collaborating
        laboratories (Dr. C.
        Sanders, University of Sheffield).</span><span
        style="font-family:"Arial","sans-serif";
        mso-fareast-font-family:"Times New
        Roman";mso-fareast-language:EN-GB"> The
        applicant will interact with members of the Birkbeck Electron
        Microscopy group (<a
          href="http://people.cryst.bbk.ac.uk/%7Eubcg16z/empage.html">http://people.cryst.bbk.ac.uk/~ubcg16z/empage.html</a>).</span></p>
    <p class="MsoNormal" style="margin-bottom:.1pt;line-height:normal"><span
style="font-family:"Arial","sans-serif";mso-fareast-font-family:"Times
        New Roman";
        mso-fareast-language:EN-GB">Applicants should have a Ph.D. (or
        equivalent) and
        be accomplished in biochemistry and structural biology<span
          style="color:black;
          layout-grid-mode:line"> or a related area, and have relevant
          research
          publications.</span> Expertise in cryo-EM structure
        determination would be
        especially desirable.   </span></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal"><span
        style="font-family:"Arial","sans-serif"">The
        laboratory is equipped with a high end Polara microscope and
        three other Tecnai
        microscopes including a 200 kV FEG system. Our Polara has a K2
        direct electron
        detector and F20 has a DE camera s that provide high resolution
        data. Funding
        has been obtained to purchase in Titan Krios with direct
        electron detector. The
        EM lab has the associated facilities for sample preparation,
        including a
        vitrobot, and a dedicated linux cluster and graphics
        workstations for image
        processing. The Birkbeck EM lab is a major focus for EM research
        and training:
        we host an EMBO course on cryo EM single particle analysis every
        2 years, and
        also an increasing number of successful research fellows. </span></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal"><span
        style="font-family:"Arial","sans-serif";
        mso-fareast-font-family:"Times New
        Roman";mso-ansi-language:EN-US;mso-fareast-language:
        EN-GB" lang="EN-US">For details and application forms please
        see: </span><span
style="font-family:"Arial","sans-serif";color:#1F497D"><a
          href="https://tinyurl.com/yda9xurm">https://tinyurl.com/yda9xurm</a></span></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal"><span
        style="font-family:"Arial","sans-serif"">Do
        not
        forget to read <span style="color:black"><a
href="https://www15.i-grasp.com/fe/wrapdev_SendFile.asp?key=116776057&c=86146598768736&pagestamp=dbvkwmngvidihrkmec&index=1">Further
            Information.pdf</a> </span></span><span
        style="font-family:"Arial","sans-serif";
        mso-fareast-font-family:"Times New
        Roman";mso-fareast-language:EN-GB"></span></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal"><b><span
          style="font-family:"Arial","sans-serif";
          mso-fareast-font-family:"Times New
          Roman";mso-fareast-language:EN-GB"> The
          closing date for completed applications is midnight on 5<sup>st
          </sup>November<sup>
          </sup>, 2017</span></b><span
        style="font-family:"Arial","sans-serif";
        mso-fareast-font-family:"Times New
        Roman";mso-fareast-language:EN-GB"></span></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal"><strong><span
          style="font-family:"Arial","sans-serif";
          color:black">Interviews will be held on Monday 20 November
          2017</span></strong><span
style="font-family:"Arial","sans-serif";mso-fareast-font-family:"Times
        New Roman";
        color:black;mso-fareast-language:EN-GB"> </span><span
        style="font-family:
"Arial","sans-serif";mso-fareast-font-family:"Times
        New Roman";mso-fareast-language:
        EN-GB"></span></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal"><span
        style="font-family:"Arial","sans-serif";color:black">For
        further information on this opportunity contact Prof Elena
        Orlova (<a href="mailto:e.orlova@mail.cryst.bbk.ac.uk">e.orlova@mail.cryst.bbk.ac.uk</a>).</span><span
style="font-family:"Arial","sans-serif";mso-fareast-font-family:"Times
        New Roman";
        mso-fareast-language:EN-GB"> </span></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal"><b style="mso-bidi-font-weight:normal"><u><span
style="font-family:"Arial","sans-serif";mso-fareast-font-family:"Times
            New Roman";
            mso-fareast-language:EN-GB">Post 2</span></u></b></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal;mso-hyphenate:none;tab-stops:center 225.65pt"><b
        style="mso-bidi-font-weight:normal"><span
          style="font-family:"Arial","sans-serif";
          mso-fareast-font-family:"Times New
          Roman";mso-fareast-language:EN-GB">Post
          Doctoral Researcher - Molecular Biology<span
            style="mso-bidi-font-weight:bold">
          </span>(Ref: </span></b><b
        style="mso-bidi-font-weight:normal"><span
          style="font-family:"Arial","sans-serif"">UOS017363</span></b><b
        style="mso-bidi-font-weight:normal"><span
          style="font-family:"Arial","sans-serif";
          mso-fareast-font-family:"Times New
          Roman";mso-fareast-language:EN-GB">)</span></b></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal;mso-outline-level:5"><b><span
          style="font-family:"Arial","sans-serif";
          mso-fareast-font-family:"Times New
          Roman";mso-fareast-language:EN-GB">Postdoctoral
          positions in molecular biology at </span></b><strong><span
          style="font-family:
"Arial","sans-serif";mso-bidi-font-weight:normal">University
          of Sheffield</span></strong><span
        style="font-family:"Arial","sans-serif"">,<b
          style="mso-bidi-font-weight:normal">
          Sheffield</b></span><b style="mso-bidi-font-weight:normal"><span
style="font-family:"Arial","sans-serif";mso-fareast-font-family:"Times
          New Roman";
          mso-fareast-language:EN-GB"> </span></b></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal;mso-outline-level:5"><b
        style="mso-bidi-font-weight:normal"><span
style="font-family:"Arial","sans-serif";mso-fareast-font-family:"Times
          New Roman";
          mso-fareast-language:EN-GB">Department of </span></b><b
        style="mso-bidi-font-weight:
        normal"><span
          style="font-family:"Arial","sans-serif"">Oncology
          &
          Metabolism</span></b><b style="mso-bidi-font-weight:normal"><span
style="font-family:"Arial","sans-serif";mso-fareast-font-family:"Times
          New Roman";
          mso-fareast-language:EN-GB"></span></b></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal;mso-hyphenate:none;tab-stops:center 225.65pt"><b
        style="mso-bidi-font-weight:normal"><span
          style="font-family:"Arial","sans-serif";
          mso-fareast-font-family:"Times New
          Roman";mso-fareast-language:EN-GB">Full
          time, fixed term appointment for up to 3 years  </span></b></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal;mso-hyphenate:none;tab-stops:center 225.65pt"><span
        style="font-family:"Arial","sans-serif"">The
        vacancy can be viewed and applied
        for via the University's job webpages - <a
          href="https://www.sheffield.ac.uk/jobs">https://www.sheffield.ac.uk/jobs</a>
        ("Current vacancies" on left-hand side, search for job reference
        UOS017363).</span><b style="mso-bidi-font-weight:normal"><span
style="font-family:"Arial","sans-serif";mso-fareast-font-family:"Times
          New Roman";
          mso-fareast-language:EN-GB"></span></b></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal;mso-hyphenate:none;tab-stops:center 225.65pt"><span
        style="font-family:"Arial","sans-serif"">Please
        look at site: <a href="http://jobs.ac.uk">jobs.ac.uk</a> - <a
href="http://www.jobs.ac.uk/job/BER940/postdoctoral-research-associate/">http://www.jobs.ac.uk/job/BER940/postdoctoral-research-associate/</a></span></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal;mso-hyphenate:none;tab-stops:center 225.65pt"><b><span
style="font-family:"Arial","sans-serif";mso-fareast-font-family:"Times
          New Roman";
          mso-fareast-language:EN-GB">The closing date for completed
          applications is
          midnight on 20<sup>st </sup>October, 2017</span></b><span
        style="font-family:
        "Arial","sans-serif""></span></p>
    <p class="MsoNormal"
      style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;
      line-height:normal;mso-hyphenate:none;tab-stops:center 225.65pt"><span
style="font-family:"Arial","sans-serif";color:black">For
        further information on
        this opportunity contact Dr Cyril Sanders </span><span
        style="font-family:"Arial","sans-serif"">(<a
href="https://www.sheffield.ac.uk/oncology-metabolism/staff/sanders">https://www.sheffield.ac.uk/oncology-metabolism/staff/sanders</a>,
        <a class="moz-txt-link-abbreviated" href="mailto:c.m.sanders@sheffield.ac.uk">c.m.sanders@sheffield.ac.uk</a> <span
          style="mso-bidi-font-weight:bold">)</span></span></p>
    <br>
    <pre class="moz-signature" cols="72">-- 
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

Prof. Elena Orlova
Crystallography, Institute for Structural and Molecular Biology, 
Department of Biological Sciences 
Birkbeck,  University of London, 
Malet Street, 
Bloomsbury 
LONDON  WC1E 7HX 
Tel: (+44) (0)20 7631 6845
Fax: (+44) (0)20 7631 6803
e-mail: <a class="moz-txt-link-abbreviated" href="mailto:e.orlova@mail.cryst.bbk.ac.uk">e.orlova@mail.cryst.bbk.ac.uk</a>

</pre>
  </body>
</html>